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wild type s ar s cov 2 spike protein subunit s1  (Sino Biological)


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    Sino Biological wild type s ar s cov 2 spike protein subunit s1
    Wild Type S Ar S Cov 2 Spike Protein Subunit S1, supplied by Sino Biological, used in various techniques. Bioz Stars score: 95/100, based on 152 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/spike+s+proteins/SARS-CoV-2+(2019-nCoV)+Spike+S1-His+Recombinant+Protein/pm41873762-43-1-22
    Average 95 stars, based on 152 article reviews
    wild type s ar s cov 2 spike protein subunit s1 - by Bioz Stars, 2026-10
    95/100 stars

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    Saline:

    Article Title: Multiplexed COVID-19 antibody quantification from human sera using label-free nanoplasmonic biosensors
    Article Snippet: .. SARS-CoV-2 Nucleocapsid (N) and Spike (S) proteins (Sinobiological, Beijing, People’s Republic of China) were prepared through dilution from 1 mg/mL stock solution to 150 μg/mL with 1x phosphate buffer saline (PBS), and Milli-Q Water, respectively; both solvents contain 0.5% trehalose (m/v) and 0.005% Tween20 (v/v). ..

    Article Title: Multiplexed COVID-19 antibody quantification from human sera using label-free nanoplasmonic biosensors
    Article Snippet: .. Protein, assay, and microarray patterning SARS-CoV-2 Nucleocapsid (N) and Spike (S) proteins (Sinobiological, Beijing, People’s Republic of China) were prepared through dilution from 1 mg/mL stock solution to 150 μg/mL with 1x phosphate buffer saline (PBS), and Milli-Q Water, respectively; both solvents contain 0.5% trehalose (m/v) and 0.005% Tween20 (v/v). ..

    Microarray:

    Article Title: Multiplexed COVID-19 antibody quantification from human sera using label-free nanoplasmonic biosensors
    Article Snippet: .. Protein, assay, and microarray patterning SARS-CoV-2 Nucleocapsid (N) and Spike (S) proteins (Sinobiological, Beijing, People’s Republic of China) were prepared through dilution from 1 mg/mL stock solution to 150 μg/mL with 1x phosphate buffer saline (PBS), and Milli-Q Water, respectively; both solvents contain 0.5% trehalose (m/v) and 0.005% Tween20 (v/v). ..



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    Box-and-whisker plots showing (A) the binding antibodies titers against SARS-CoV-2 S1, RBD and S2 spike antigens (B) the ratios between S1/S2 and RBD/S2 binding titers and (C) the Fc-receptor antibody-mediated ADCC and ADCP activities against <t>SARS-CoV-2</t> <t>full-length</t> spike in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal lines showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. D) Heatmap of Spearman correlation matrices between SARS-CoV-2 antibody titers (ADCC, ADCP, nAb and IgG binding titers against S, S1, S2 and RBD) at days 0, 3, 7 and 46 post-recruitment. Statistically significant correlations in the underlined intersections are indicated with asterisk (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001). E) Spearman correlations between binding IgG antibodies against S1, RBD or S2 domains and functional ADCC (blue) or ADCP (purple) antibodies at each timepoint. Each dot represents a sample. Shown are the Spearman r coefficient, 95% confidence interval (CI) and p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns, not significant). Data is also shown in Supplementary Table 2.
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    Box-and-whisker plots showing (A) the binding antibodies titers against SARS-CoV-2 S1, RBD and S2 spike antigens (B) the ratios between S1/S2 and RBD/S2 binding titers and (C) the Fc-receptor antibody-mediated ADCC and ADCP activities against SARS-CoV-2 full-length spike in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal lines showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. D) Heatmap of Spearman correlation matrices between SARS-CoV-2 antibody titers (ADCC, ADCP, nAb and IgG binding titers against S, S1, S2 and RBD) at days 0, 3, 7 and 46 post-recruitment. Statistically significant correlations in the underlined intersections are indicated with asterisk (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001). E) Spearman correlations between binding IgG antibodies against S1, RBD or S2 domains and functional ADCC (blue) or ADCP (purple) antibodies at each timepoint. Each dot represents a sample. Shown are the Spearman r coefficient, 95% confidence interval (CI) and p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns, not significant). Data is also shown in Supplementary Table 2.

    Journal: medRxiv

    Article Title: Early Fc-effector antibody signatures impact COVID-19 disease trajectory

    doi: 10.64898/2026.02.18.26346542

    Figure Lengend Snippet: Box-and-whisker plots showing (A) the binding antibodies titers against SARS-CoV-2 S1, RBD and S2 spike antigens (B) the ratios between S1/S2 and RBD/S2 binding titers and (C) the Fc-receptor antibody-mediated ADCC and ADCP activities against SARS-CoV-2 full-length spike in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal lines showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. D) Heatmap of Spearman correlation matrices between SARS-CoV-2 antibody titers (ADCC, ADCP, nAb and IgG binding titers against S, S1, S2 and RBD) at days 0, 3, 7 and 46 post-recruitment. Statistically significant correlations in the underlined intersections are indicated with asterisk (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001). E) Spearman correlations between binding IgG antibodies against S1, RBD or S2 domains and functional ADCC (blue) or ADCP (purple) antibodies at each timepoint. Each dot represents a sample. Shown are the Spearman r coefficient, 95% confidence interval (CI) and p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns, not significant). Data is also shown in Supplementary Table 2.

    Article Snippet: All recombinant proteins used in this study were purchased from Sino Biological: SARS-CoV-2 full-length spike (S) protein (Cat. #40589-V08H4), seasonal HCoV-OC43 full-length S (Cat. #40607-V08B), seasonal HCoV-229E full-length S (Cat. #40605-V08B), SARS-CoV-2 S1 domain (Cat. #40591-V08H), SARS-CoV-2 S2 domain (Cat. #40590-V08H1), SARS-CoV-2 RBD subdomain (Cat. #40592-V08H80), HCoV-OC43 S1 domain (Cat. #40607-V08H1) and HCoV-OC43 S2 domain (Cat. #40607-V08B1).

    Techniques: Whisker Assay, Binding Assay, MANN-WHITNEY, Functional Assay

    A) Heatmap of FcγR-binding antibody responses to SARS-CoV-2 S antigens in mild and severe COVID-19 patients. Binding activity of antibodies to FcγRs was measured for SARS-CoV-2 full-length S, S1 and S2 antigens at days 0, 3, 7, and 46 post-recruitment. Box-and-whisker diagrams showing (B) FcγR2AH and FcγR2AR-binding antibody responses (C) FcγR3AV and FcγR3AF-binding titers, (D) functional monocyte antibody-dependent cellular phagocytosis (ADCP) responses and (E) functional antibody-dependent neutrophil phagocytosis (ADNP) responses against SARS-CoV-2 full-length S, S1 and S2 antigens in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal line showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. F) PCA of antibody responses according to day of recruitment (day 0: blue; day 3: red; day 7: green and day 46: purple). Empty circles represent mild cases, and filled circles represent severe cases. Ellipses show 95% confidence regions. G) Spider plot of the antibody landscape (IgG antibody titers, FcγR-binding activity and FcγR-effector functions) in mild and severe COVID-19 patients. Median percentile for each antibody feature is shown at each timepoint and for each SARS-CoV-2 S antigen.

    Journal: medRxiv

    Article Title: Early Fc-effector antibody signatures impact COVID-19 disease trajectory

    doi: 10.64898/2026.02.18.26346542

    Figure Lengend Snippet: A) Heatmap of FcγR-binding antibody responses to SARS-CoV-2 S antigens in mild and severe COVID-19 patients. Binding activity of antibodies to FcγRs was measured for SARS-CoV-2 full-length S, S1 and S2 antigens at days 0, 3, 7, and 46 post-recruitment. Box-and-whisker diagrams showing (B) FcγR2AH and FcγR2AR-binding antibody responses (C) FcγR3AV and FcγR3AF-binding titers, (D) functional monocyte antibody-dependent cellular phagocytosis (ADCP) responses and (E) functional antibody-dependent neutrophil phagocytosis (ADNP) responses against SARS-CoV-2 full-length S, S1 and S2 antigens in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal line showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. F) PCA of antibody responses according to day of recruitment (day 0: blue; day 3: red; day 7: green and day 46: purple). Empty circles represent mild cases, and filled circles represent severe cases. Ellipses show 95% confidence regions. G) Spider plot of the antibody landscape (IgG antibody titers, FcγR-binding activity and FcγR-effector functions) in mild and severe COVID-19 patients. Median percentile for each antibody feature is shown at each timepoint and for each SARS-CoV-2 S antigen.

    Article Snippet: All recombinant proteins used in this study were purchased from Sino Biological: SARS-CoV-2 full-length spike (S) protein (Cat. #40589-V08H4), seasonal HCoV-OC43 full-length S (Cat. #40607-V08B), seasonal HCoV-229E full-length S (Cat. #40605-V08B), SARS-CoV-2 S1 domain (Cat. #40591-V08H), SARS-CoV-2 S2 domain (Cat. #40590-V08H1), SARS-CoV-2 RBD subdomain (Cat. #40592-V08H80), HCoV-OC43 S1 domain (Cat. #40607-V08H1) and HCoV-OC43 S2 domain (Cat. #40607-V08B1).

    Techniques: Binding Assay, Activity Assay, Whisker Assay, Functional Assay, MANN-WHITNEY